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μCapsul™ controlled-release polymer

μCapsul™ is a bioabsorbable copolymer consist of mPEG and poly(lactide-co-glycolide). The defining feature of μCapsul™ is its temperature reversible sol-gel transition. Cool μCapsul™ appear in liquid form and alter to gel form in body temperature.

In the gel state, the highly lipophilic and network structure of the μCapsul™ allow it to become an efficient vehicle for localized administration of protein and small molecules, especially for hydrophilic factors. By maintaining these factors a high local concentration, we create a reservoir for these factors and can be released slowly over time.

Features

  • 100% synthetic, pathogen free
  • Temperature reversible sol-gel transition
  • Excellent biocompatibility and biodegradability
  • Manufactures in ISO 13485 certified facilities
  • FDA MAF registration: MAF 3119

Typical Applications

  • Localized delivery of antibiotis/peptide/analgesics/vaccine
  • Tissue engineering
  • Regenerative medicine
  • Tissue anti-adhesion barrier

Specification

Concentration ± 15%
Endotoxin LAL < 0.5 EU/ml
Heavy Metals ≤ 10 ppm

Available Options

μCapsul™ controlled-release polymer (Solution form)

Specification Sterility Catalog No. Package
<0.5 EU/ml, 15% Sterile B00-04MA-15B 3ml

We also cooperate with our customer to co-develop formulations, components, and finished products. If you would like to know more about our services or have any other questions, please contact us.

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Datasheet

Reference

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Studies on the preparation and characterization of mPEG-polyester biodegradable bioglue for bone defect repair.

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Controlled release of cyclosporine A from biodegradable amphiphilic diblock copolymer sol-gel drug delivery system.

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Study of novel biodegradable thermo-sensitive hydrogels of methoxy-poly(ethylene glycol)-block-polyester diblock copolymers.

 Journal of Immunology. 2010 Nov 1;185(9):5468-75.

Hydrogel-delivered GM-CSF overcomes nonresponsiveness to hepatitis B vaccine through the recruitment and activation of dendritic cells.

Biomaterials. 2010 Jul;31(19):5227-36.

Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles.